Do diosgenin ameliorate urinary bladder toxic effect of cyclophosphamide and buthionine sulfoximine in experimental animal models?
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چکیده
منابع مشابه
Cyclophosphamide and urinary bladder toxicity.
Single doses of cyclophosphamide can regularly induce bladder damage in rats and dogs. Changes develop rapidly and, within ~4 hours, consist of ulceration of the mucosal epithelium, hemorrhage and edema in all bladder tissues, and necrosis in smooth muscle and small arteries. The epithelium and submucosa of the renal pelvis are similarly affected. Renal tubular necrosis is seen in a minority of...
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Neurogenic bladder is related to various types of neurogenic disease and injury, including cerebrovascular accident, brain tumor, spinal cord injury, and Parkinson's disease. The results of urodynamic study show different types of detrusor and sphincter function. According to these urodynamic results, the physician decides on a treatment plan, such as anticholinergics or alpha-blockers. In the ...
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23 Buthionine sulfoximine (BSO) is a specific inhibitor of γ-glutamylcysteine synthetase, thus 24 blocking the synthesis of glutathione (GSH). It is known that this makes that BSO affects melanin 25 synthesis because of the role of thiols in melanogenesis. However, BSO may also react with the 26 intermediate oxidation products of melanogenesis, a possibility that has not been investigated from ...
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Oxidative stress and genomic rearrangements play a role in cancer development. l-Buthionine-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting gamma-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH). We postulated that oxidative stress induced by GSH depletion might lead to genomic rearrangements, such as DNA deletions, and that...
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ژورنال
عنوان ژورنال: African Journal of Biotechnology
سال: 2012
ISSN: 1684-5315
DOI: 10.5897/ajb11.2068